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The genetics of diabetes
(Better titled: "What are
the odds of my getting diabetes?")*
| Type 1 Diabetes:
 | If your mother has Type 1 diabetes, you
have a 3% risk of developing Type 1 diabetes. |
 | If your father has Type 1 diabetes, you
have a 6% risk of developing Type 1 diabetes. |
 | If both your parents have Type 1
diabetes, you have a 30% risk of developing Type 1 diabetes. |
 | If your brother or sister has Type 1 diabetes,
you have a 5% risk of developing Type 1 diabetes. |
 | If your non-identical twin has Type 1
diabetes, you have a 20% risk of developing Type 1 diabetes. |
 | If your identical twin has Type 1
diabetes, you have a 35% risk of developing Type 1 diabetes.** |
 | If there is no family history of diabetes, you
have a 0.2% risk of developing Type 1 diabetes (by the age of 20). |
Type 2 Diabetes:
 | If your mother or father has Type 2 diabetes,
you have a 15% risk of developing Type 2 diabetes. |
 | If both your parents have Type 2
diabetes, you have a 75% risk of developing Type 2 diabetes. |
 | If your brother or sister has Type 2 diabetes,
you have a 10% risk of developing Type 2 diabetes. |
 | If your non-identical twin has Type 2
diabetes, you have a 10% risk of developing Type 2 diabetes. |
 | If your identical twin has Type 2 diabetes,
you have a 90% risk of developing Type 2 diabetes. |
*These figures are approximations.
Quite different estimates of risk show up on different studies from
different parts of the world. The estimates listed above are most
applicable to North America. Also (and importantly), remember that at least for
Type 2 diabetes these risks can be substantially reduced by appropriate
intervention with diet, exercise and sometimes, with medication. **Can you think
of a better illustration of the fact that Type 1 diabetes is clearly a
mixture of both a genetic susceptibility and an
environmental trigger? If it was all genetic then, if your
identical twin had Type 1 diabetes, you would have a 100% risk of
developing Type 1 diabetes. So what is the non-genetic factor?
What in the environment triggers Type 1 diabetes in susceptible
individuals? Is it a virus? Something in the diet (such as
nitrosamines in smoked meat)? Is it early exposure to cow's milk?
We don't know, of course, and there is ongoing research to figure it out,
including the exciting
TRIGR study which is
looking at the latter possibility. Also of
interest is that although we speak of family history as being so
important, at most only 15% of people with Type 1 diabetes have a first
degree relative (brother, sister, father, mother, son or daughter) with
Type 1 diabetes. If you are really
interested in the genetics of diabetes and the predictability of getting
Type 1 diabetes based on genetic and antibody studies have a look at an
article in the medical journal, "Clinical Diabetes". |
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